Povidone

PVP (Polyvinylpyrrolidone) CAS NO.:9003-39-8 Structure: Properties: White or creamy white powder, odourless, nontoxic, non-irritant, dissolves readily in water, alcohol, amine and many other organic solvents. PVP K 30 is widely used in pharmaceutical fields, thanks to it’s excellent solubility,...
Product description

PVP (Polyvinylpyrrolidone)

CAS NO.:9003-39-8

Structure:

1.jpg


Properties:
White or creamy white powder, odourless, nontoxic, non-irritant, dissolves readily in water, alcohol, amine and many other organic solvents. PVP K 30 is widely used in pharmaceutical fields, thanks to it’s excellent solubility, film-forming capability, chemical stability, physiological inertia and cement ability.


Specifications: 

Conforms to standard USP . EP.  

Item   (PVP K30)

Specification

Appearance

White or yellowish-white powder or flakes

Identification

Positive

Appearance of solution

Colorless

PH

3.0-7.0

Viscosity (Express as K-Value)

27-32

Aldehydes(Express as acetaldehyde)

≤500 ppm

Peroxides(Expressed as H2O2)

≤400 ppm

Hydrazine

≤1.0 ppm

N-Vinylpyrrolidone

≤10 ppm

Heavy Metals

≤10 ppm

Water

≤5.0%

Residue on Ignition

0.1%

Nitrogen Content

11.5-12.8% of Nitrogen

Total Aerobic plate count CFU/g

≤100

Mold/Yeast, CFU/g

≤100

Staphylococcus Aureus, CFU/g

Negative

Salmonella, CFU/g

Negative

Pseudomonas aeruginosa, CFU /g

Negative

E.co.I CFU/g

Negative


Application:
PVP products possess excellent adhesive, film-forming, dispersing and thickening properties, which are widely used in the pharmaceutical industry. They are one of the three main  accessory  products recognized & approved worldwide.


General Summarization:

*Low molecular weight PVP, for use as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injectables and ophthalmic formulations. Such as PVP K12,K15,K17.*Medium Molecular PVP, for use as binder in tablets, capsules and granular, as a stabilizer for oral suspensions, film-forming agent, soluilizing agent, dispersant for pigments, as an enzyme stabilizer and to improve bioavailability. e.g. PVP K25,K30.*High molecular ,a highly effective binder, for us as stabilizer in oral and topical suspensions, as a thickener, hydropilizing agent e.g. PVP K60,K90.

1. Binder of Tablets: PVP K25,K30,K90 all possess high binding strengths, they are suitable for the wet granulation and direct compression of tablets. KoVidoneTMK25 is used more than K30 and K90,due to its low viscosity. Conversely, KoVidoneTMK90 is used less due to its high binding properties.

2. Solubilizers, Solvents and Crystallization inhibitors: Low molecular weight PVP K12,K15,K17 are intended for use as solubilizing agents, dispersants and crystallization inhibitors, suspension stabilizers for injections and ophthalmic products.

3. Dispersant or co-precipitator agent: PVP K25 or K30 act as a co-milling or co-precipitation agent in drugs which do not dissolve readily, and will greatly improve the dissolutions rate of the drug. The method used is to mix the PVP and drug, and then spray this onto a carrier, granulation or tablet.

4. Suspension stabilizer: PVP K25, K30 andK90 are suitable for the stabilizing of suspensions with a wide range of active ingredients; the results will be improved if PVP K90 is used with Poly PVP.

5. Film/sugar Coatings, film formers: PVP K25, K30 act a film-forming agents, adhesion promoters and pigment dispersers, and are often used as sugar coating and film coating.

6. Thickening agents: KoVidoneTMK90 is suitable for use as a thickening agent for aqueous-alcoholic solutions for oral and topical suspensions.

7. Pore-former: PVP K30 can be applied as pore-former in taste-masking formulations and K90 can be as pore forming agent in medical plastics.

8. Improvement bioavailability, controlled release aid: PVP K12, K15, K17,K30, K90 can be used to adjust the dissolving speed of some hardly soluble actives.

9. Food Fields: PVP K25, K30, K60,K90 can be used in dietetic tablets, e.g. Vitamin, dietary fiber tablets, sweeteners.

10.Other Applications: capsule flow aid , cleaning fluids for contact lenses, enzyme and sensitive medicines stabilization, cry protector.


Remarks: 

PVP is available for Cosmetic/Personal care applications, they are requested subject to special quality and purity controls of the cosmetic/personal care formulations needed.

 

包装图片.jpg


 


Hot Tags: povidone, China, manufacturers, factory, customized, DMF, USP, buy, free sample, made in China
Related Products
Feedback

Copyright © Tianjin ILE Pharmaceutical Materials Co.,Ltd All Rights Reserved.Tel: +86-22-83716586