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CFDA Prompting Attention On Liver Injury Risk Of Oral Polygoni Multiflori
Nov 01, 2018

CFDA Prompting Attention on Liver Injury Risk of Oral Polygoni Multiflori


July 22, 2014 By CPhI.cn


Case report database of Chinese pharmaceutical products adverse reactions has successively received case reports of oral polygoni multiflori and its prescription preparations causing liver injury: it is considered that oral polygoni multiflori and its prescription preparations do damage to liver to a certain extent after the analysis of relevant cases and comprehensive assessment in combination with relevant literature report. polygoni multiflori is divided into raw polygoni multiflori and radix polygoni multiflori preparata. Case reports indicate that the liver injury risk of radix polygoni multiflori preparata is lower than that of raw polygoni multiflori. And there is no case report collected on liver injury caused by polygoni multiflori for external use currently.


CFDA prompts: I. Before using polygoni multiflori and its prescription preparations, medical personnel shall fully understand the drug-induced risk, learn the diseases history and medication history of the patient in detail, pay attention to the dosage and the course of treatment, avoid using other pharmaceutical products that may cause liver injury, and shall avoid using polygoni multiflori and its prescription preparations for patient with hepatic insufficiency. II. Before using polygoni multiflori and its prescription preparations, the patient shall carefully read the pharmaceutical directions and take the drug in strict accordance with the usage and dosage of the directions , or take the drug under the guidance of the doctor and avoid using drug for a long time. In case of any abnormal biochemical index of liver or suspicious adverse reaction during drug taking, the patient shall immediately stop taking the drug and go to the doctor.


CFDA is actively organizing the relevant agency to carry out exploratory development on the ingredient, dosage, mechanism, etc. of polygoni multiflori causing liver injury in hope of taking more effective measures to maintain the safety of diet and drug use for the public.





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