Aqueous Ethyl Cellulose Dispersion -RS

EASTROL®– RA(Professional Type)

DMF AVALIABLE

Application Properties

By itself, EASTROL®– RA (Ethyl Cellulose Dispersion) is unable to achieve good drug release effects, and in order to obtain optimal release, the film thickness, type of plasticizer and other additives need to be considered, in addition to the drug’s properties.

1. Plasticizer

When using EASTROL®– RA (Ethyl Cellulose Dispersion), the appropriate plasticizer (such as, DBS, TEC, DEP, etc.) must be selected according to the target drug release profile. The recommended plasticizer for use with EASTROL®– RA is DBS, at the suggested use level of 20-25% of solids content.

2. Use of Pore formers

Pore formers are typically certain types of surfactants, water-soluble small molecules and/or film forming materials. The addition of pore formers will affect the permeability of the film formed by EASTROL®– RA and hasten drug release rates.

3. Anti-adherent use

To avoid the possibility of drug particle sticking affecting coating operations, the correct quantity of anti-adherent(such as, Talc, etc.) and inorganic colorants (such as, pigments, Titanium Dioxide, etc.) can be added. EASTROL® – RA is compatible with ethanol-dispersed colorants. It is suggested that the plasticizer is added first and stirring undertaken for 2hours before the colorant is added.  Note that single color coating of the EASTROL®– RA film is preferred.

4. Coating equipment

A wide range of coating machines can be used with this product, however, for superior coating effects,the use of a coating machine with high drying efficiency and bottom spray application is recommended.